102 - Oxygen Medicine - SonoDynamic Therapy (SDT):

Cell Killing Mechanism of Sonosensitizers using 102 Singlet Oxygen in SonoDynamic Therapy (SDT) Treatments

http://ar.iiarjournals.org/search?fulltext=oxygen++therapy&submit=yes&x=0&y=0

http://ar.iiarjournals.org/content/27/6A/3673.full.pdf+html?sid=3d372ceb-776d-490e-91b7-e75e859f35e7

Abstract:

In 1O2 PhotoDynamic Therapy (PDT), when a photosensitizer is exposed to specific wavelengths of light, it is activated from its ground state intoan excited state, and as the activated sensitizer returns to the ground state, the energy released can generate reactive oxygen species ROS, such as 102 singlet oxygen, and free radicals which mediate the direct cellular toxicity (19). The mechanism of the cytotoxicity in 1O2 SonoDynamic Therapy (SDT) seems to be theoretically similar to that in 1O2 PhotoDynamic Therapy (PDT).

In our study, L-histidine, a reactive oxygen scavenger of singlet oxygen and hydroxyl radicals (22, 23), reduced the sonotoxicity of DCPH-PNa(I), but D-mannitol, a scavenger of hydroxyl radicals, hardly affected the sonotoxicity.

Thus suggesting that singlet oxygen is more important than hydroxyl radicals for the sonotoxicity of DCPH-P-Na(I) (18).

http://ar.iiarjournals.org/search?fulltext=oxygen++therapy&submit=yes&x=0&y=0

http://ar.iiarjournals.org/content/27/6A/3673.full.pdf+html?sid=3d372ceb-776d-490e-91b7-e75e859f35e7